Handbook of Neuroemergency Clinical Trials
Reduzierte Artikel in dieser Kategorie
13,99 €
| Verlag | Academic Press |
| Auflage | 2017 |
| Seiten | 400 |
| Format | 19,1 x 24,4 x 2,4 cm |
| Gewicht | 1000 g |
| Artikeltyp | Englisches Buch |
| ISBN-10 | 0128040645 |
| EAN | 9780128040645 |
| Bestell-Nr | 12804064EA |
Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials.
This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors pr ovide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development.
Inhaltsverzeichnis:
ACUTE ISCHEMIC STROKE
1. Acute Ischemic Stroke
2. Subarachnoid Hemorrhage
3. Clinical Trials in Spontaneous Intracerebral Hemorrhage
4. Imaging Biomarkers in Stroke Trials
TRAUMATIC BRAIN INJURY
5. Traumatic Brain Injury
6. Improving approaches to evaluate efficacy and safety of drugs for traumatic brain injury
7. Brain Imaging in Traumatic Brain Injury
8. The Use of Blood-Based Biomarkers to Improve the Design of Clinical Trials of Traumatic Brain Injury
9. Biostatistical Issues in TBI Clinical Trials
SEIZURE EMERGENCIES
10. Acute Seizures and Status Epilepticus
11. Post-traumatic Seizures
NONTRAUMATIC NEUROEMERGENCIES
12. Neuroemergencies in Critical Care Patients
13. Neuro-Emergency Clinical Trials: Migraine
14. Acute Visual Deficits
DEVICES FOR NEUROEMERGENCIES
15. Implications for new trials in acute ischemic stroke in the new era of endovascular therapy
KEY ISSUES IN NEUROEMERGEN CY CLINICAL TRIALS
16. The Role of a Project Medical Officer in Acute Neuroemergency Clinical Studies
17. Regulatory Considerations
18. Military Perspectives on Brain Injuries: Implications for Clinical Trials
