Brain Edema - From Molecular Mechanisms to Clinical Practice

Brain Edema: From Molecular Mechanisms to Clinical Practice brings together the most widely recognized experts in experimental and clinical brain edema research to review the current knowledge gathered on the molecular and cellular pathophysiology and clinical management of brain edema. This timely book also discusses future directions of research and treatment.

Brain edema is an integral and acutely life-threatening part of the pathophysiology of multiple cerebral and non-cerebral disorders, including traumatic brain injury, cerebral ischemia, brain tumors, cardiac arrest, altitude sickness and liver failure. Affecting millions worldwide, research over the past few years has shown that a plethora of complex molecular and cellular mechanisms contribute to this pathological accumulation of water in the brain parenchyma.

In parallel, the development of new neuroimaging tools has provided a new way to examine how edema develops longitudinally and in real time, both in pre-clinical models and in patients. Despite intense research over the past few decades, therapeutic options are still limited and sometimes not effective.

Inhaltsverzeichnis:

Introduction: Brain edema formation - significance for patient outcome

Section 1. General Introduction
1. Physiology of cerebral blood vessels
2. Blood-brain interfaces organization in relation to inorganic anion transport, CSF secretion and circulation

Section 2. Techniques to investigate cerebral blood
3. Imaging techniques for brain edema: from basic science to the clinic
4. Experimental techniques to investigate the formation of brain edema in vivo
5. In Vitro Models of the Blood-Brain Barrier to Better Understand the Pathophysiology of Brain Edema

Section 3. Molecular basis and concepts in brain edema formation for new treatment development
6. The extracellular and perivascular spaces of the brain
7. Blood brain barrier mechanisms of edema formation: The role of ion transporters and channels
8. Mechanisms of cell volume regulation in the central nervous system
9. Role of aquaporins for the formation and resolution of b rain edema
10. Sur1-Trpm4 - promising target for brain edema treatment
11. Role of Matrix Metalloproteinases in Brain Edema

Section 4. Brain edema process in pre-clinical models
12. Edema and BBB Breakdown in Stroke
13. Brain edema formation in traumatic brain injury
14. Spinal cord edema after spinal cord injury: From pathogenesis to management
15. Brain Edema in Acute Liver Failure
16. Blood-Brain Barrier and Edema in Brain Tumors
17. Water homeostasis dysfunction in epilepsy
18. Water homeostasis dysfunctions and edema in neuroinflammatory disease
19. Experimental therapies for brain edema and intracranial hypertension

Section 5. Clinical features and management of brain edema
20. Clinical monitoring of brain edema
21. Brain edema in developing brain diseases
22. Cerebral edema in cerebrovascular diseases
23. Traumatic brain injury and edema treatment
24. Treatment of edema formation in oncology
25. Perspectiv es on future translational research on brain edema