Applied Immunohistochemistry in the Evaluation of Skin Neoplasms

This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. The book reviews in detail the sensitivity and specificity of commonly available antibodies and their pattern of immunostaining. readers will learn when to order antibodies and how to interpret findings. In addition, prognostic markers are evaluated and emphasis placed on the pitfalls commonly encountered when evaluating these neoplasms. The text is complemented by a wealth of superb images. Helpful histograms and algorithms are included, and clear guidance is provided on the application and interpretation of less commonly used antibodies and immunostains. Applied Immunohistochemistry in the Evaluation of Skin Neoplasms will serve as an extremely valuable resource for practicing dermatopathologists and pathologists .

Inhaltsverzeichnis:

Contents

Listof Contributors


PartI: Immunohistology of Epithelial Tumors


1 Immunohistology and Molecular Studiesof Epithelial Tumors


Heather M. Froehlich and Jose A.Plaza




Part II: AdnexalNeoplasms


2 Immunohistology and Molecular Studiesof Sweat Gland Tumors

Ana M. Molina-Ruiz, Laura Fuertes,and Luis Requena



3 Immunohistology and Molecular Studiesof Follicular Tumors

Olayemi Sokumbi and Jose A. Plaza

4 Use of Immunohistochemical andMolecular Studies in the Evaluation of the Sebaceous Neoplasms




Doina Ivan, Victor G. Prieto, andPhyu P. Aung



Part III:Immunohistology of Cutaneous Metastases and Its Simulators




5 Cutaneous Metastasis

Danielle M. Wehle, Sadia Salim, andMartin A. Sangueza



Part IV:Immunohistology of Mesenchymal Neoplasms




6 Immunohistol ogy and Molecular Studiesof Fibrohistiocytic and Myofibroblastic Cutaneous Tumors


Danny Ghazarian, Sebastien Labonte,Brendan Craig Dickson, and Ayman Al Habeeb

7 Immunohistology and Molecular Studiesof Smooth Muscle and Neural Cutaneous Tumors


Tammie Ferringer

8 New Insights in Vascular LesionsDevelopment and Identification with Immunohistochemical Markers


Omar P.Sangüezaand Julio A. Diaz-Perez



Part V:Immunohistology of Cutaneous Lymphoma




9 Immunohistology and Molecular Studiesof Cutaneous B-cell Lymphomas


Juan F. García

10 Immunohistology and Molecular Studies ofCutaneous T-cell Lymphomas and Mimics


Carlos A. Torres-Cabala, Phyu P.Aung, Roberto N. Miranda, and Jonathan L. Curry

11 Immunohistology of Leukemia Cutis andHistiocytic Tumors


Maria Teresa Fernández Figueras,Gustavo Tapia, José Luis Mate, Aurelio Ariza



Part VI:Immunohistology of Melanocytic Lesions



12 Immunohistology of Melanocytic Lesions
Jonathan L. Curry, Michael T.Tetzlaff, Priyadharsini Nagarajan, and Carlos A. Torres-Cabala




Part VII:Molecular Studies of Melanocytic Lesions


13 Molecular Studies of Melanocytic Lesions


Rami Al-Rohil, PriyadharsiniNagarajan, and Michael T. Tetzlaff



Part VIII:Immunohistology of Sentinel Lymph Node in Melanoma



14 Sentinel Lymph Node in Melanoma

Victor G. Prieto