Organometallic Chemistry in Industry - A Practical Approach

Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studiesThis comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, an d execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more.-Includes rare industrial case studies difficult to find in current literature-Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation-Features a foreword by Nobel Laureate R. H. Grubbs-A perfect resource for every R&D researcher in industry-Useful for PhD students and postdocs: excellent preparation for a job interviewOrganometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.

Inhaltsverzeichnis:

INDUSTRIAL MILESTONES IN ORGANOMETALLIC CHEMISTRYDESIGN, DEVELOPMENT AND EXECUTION OF A CONTINUOUS FLOW ENABLED API MANUFACTURING ROUTECONTINUOUS MANUFACTURING AS AN ENABLING TECHNOLOGY FOR LOW TEMPERATURE ORGANOMETALLIC CHEMISTRYDEVELOPMENT OF A NICKEL-CATALYZED ENANTIOSELECTIVE MIZOROKI-HECK COUPLINGDEVELOPMENT OF IRON-CATALYZED KUMADA CROSS-COUPLING FOR THE LARGE SCALE PRODUCTION OF ALISKIREN INTERMEDIATEDEVELOPMENT AND SCALE-UP OF A PALLADIUM-CATALYZED INTRAMOLECULAR DIRECT ARYLATION IN THE COMMERCIAL SYNTHESIS OF BECLABUVIRRUTHENIUM CATALYZED C-H ACTIVATED C-C/N/O BOND FORMATION REACTIONS FOR THE PRACTICAL SYNTHESIS OF HETEROCYCLES AND PHARMACEUTICAL AGENTSCROSS-COUPLINGS IN WATER - A BETTER WAY TO ASSEMBLE NEW BONDSASPECTS OF HOMOGENEOUS HYDROGENATION FROM INDUSTRIAL RESEARCHLATEST INDUSTRIAL USES OF OLEFIN METATHESISDEHYDRATIVE DECARBONYLATION